When Less Might Be More

Metronomic Chemotherapy: When Less May Be More

The use of low dose continuous schedules of chemotherapy (i.e. metronomic chemotherapy), delivered at lower doses by necessity compared to traditional dosing schemes, has become an increasingly popular addition to patient management in veterinary medical oncology. While the concept itself is not new, as low dose, maintenance chemotherapy protocols have been important components of treatment for...

Macromolecular crowding in vitro as means of emulating cellular interiors: when less might be more.

Fascinating evidence was presented recently that monocrowding with Ficoll 70 (Fc70) improves the refolding speed of VlsE that was unfolded in urea (1). This demonstrated the power of macromolecular crowding as present in cellular interiors. However, we noted that the Fc70 concentrations used in this study (1) are high enough to cause self-crowding (2), meaning compaction of the crowder, thus di...

When Less is More

engine and airframe manufacturers for decades have cited the direct relationship between engine wear and high exhaust gas temperature (EGT) in recommending that operators use less than maximum takeoff thrust whenever possible. While the cost benefits of reduced-thrust takeoffs are thoroughly documented, the safety benefits are not as well understood. Thus, there is a common perception that usin...

When Less is More.

minimum level. Sometimes more really is more, and less really is less. But often, less is more. If all this piece does is open up the question of whether less is more —if all it does is remind the reader that this is a question, and that our answers to it have important repercussions— then it will have served its purpose. Many ethicists in the ancient tradition argued that human lives could be ...

Introduction: When More Becomes Less